Xbira 250mg Tablet (Abiraterone Acetate) – Treatment for Prostate Cancer

Xbira 250mg Tablet contains abiraterone acetate, a targeted therapy used to treat metastatic prostate cancer that has spread to other parts of the body. This medication works by significantly reducing testosterone production, which fuels prostate cancer growth. It’s typically prescribed with prednisolone to enhance effectiveness and manage side effects. Patients should take it on an empty stomach (1 hour before or 2 hours after meals) for optimal absorption. While effective, it requires regular monitoring of liver function, blood pressure, and potassium levels. A patient assistance program is available in India through Tata 1mg for eligible patients.

Uses of Xbira 250mg Tablet:

Treatment of metastatic castration-resistant prostate cancer (mCRPC)
Therapy for high-risk metastatic hormone-sensitive prostate cancer
Used in combination with prednisolone for enhanced efficacy

Benefits of Xbira 250mg Tablet:

Xbira 250mg Tablet extends survival in advanced prostate cancer patients by blocking testosterone production throughout the body (not just in testes). Clinical studies show it can delay disease progression by 16-18 months when combined with standard therapy. Patients often experience reduced pain and improved urinary symptoms. Unlike chemotherapy, it specifically targets cancer’s hormonal drivers with generally better tolerability.

Side Effects of Xbira 250mg Tablet:

Very common side effects (affecting >1 in 10 users):
– Fluid retention – High blood pressure – Low potassium levels
– Liver enzyme increases – Fatigue – Joint pain
Serious risks requiring immediate medical attention:
– Severe liver problems – Heart rhythm abnormalities – Adrenal insufficiency

How to Use Xbria 250mg Tablet?

Take 4 tablets (1000mg total) once daily on an empty stomach – at least 1 hour before or 2 hours after food. Swallow whole with water – never crush or chew. Always take with 5mg prednisolone twice daily as prescribed to manage side effects. Regular blood tests are essential throughout treatment.

How Medicine Works?

Xbira 250mg Tablet inhibits CYP17 enzymes (17α-hydroxylase and C17,20-lyase) that are crucial for androgen (male hormone) production. This dual blockade occurs in:

Testes
Adrenal glands
Prostate tumor tissue itself

By cutting off testosterone supply at multiple sources, it effectively starves hormone-dependent prostate cancer cells.

Safety Advice:

Liver function: Requires weekly monitoring for first month
Heart health: ECG monitoring if history of heart conditions
Pregnancy: Absolutely contraindicated – may harm fetus
Contraception: Required for men with female partners
Drug interactions: Many significant interactions
Food interactions: Avoid with meals – reduces absorption

What If You Missed a Dose?

If you miss a dose, take it as soon as remembered unless it’s within 12 hours of next dose. Never take extra tablets to compensate. If vomiting occurs after dosing, don’t repeat the dose – continue with the next scheduled dose.

FAQs:

Q1: Why must I take Xbira 250mg Tablet on an empty stomach?

Food increases drug absorption by 5-10 times, potentially causing dangerous side effects. Taking it properly fasted ensures consistent, safe medication levels.

Q2: How long until I see improvement?

PSA levels typically begin dropping within 4-8 weeks, with symptom relief often following. Full response assessment requires 3-6 months of treatment and imaging.

Q3: Why is prednisolone prescribed with Xbira 250mg Tablet?

Prednisolone prevents mineralocorticoid excess caused by Xbira – reducing risks of high blood pressure, fluid retention, and potassium loss that could otherwise occur.

Q4: Can I take painkillers with this medication?

Some NSAIDs may interact – consult your oncologist. Paracetamol is generally safe if liver function is normal. Always report new medications.

Q5: Will this affect my sex life?

Yes, testosterone suppression typically causes loss of libido and erectile dysfunction. Discuss management options with your doctor.

Q6: What liver symptoms require immediate attention?

Stop Xbira and call your doctor immediately for:
– Yellow skin/eyes – Dark urine – Severe nausea
– Right upper abdominal pain – Unusual bleeding/bruising