Ostospray Nasal Solution – Calcitonin for Osteoporosis Management

Ostospray contains Salmon Calcitonin (200 IU), a synthetic hormone used in the treatment of postmenopausal osteoporosis and Paget’s disease of bone. It works by inhibiting osteoclastic bone resorption, thus preserving bone mass and reducing the risk of fractures.

Uses of Ostospray:

• Treatment of osteoporosis in postmenopausal women
• Management of Paget’s disease
• Relief from bone pain due to osteolysis or bone metastases (in some cases)

How Ostospray Works?

Ostospray acts as a calcitonin receptor agonist. It binds to osteoclast receptors and suppresses their bone-resorbing activity. This leads to a decrease in bone turnover and a reduction in calcium release from bones, thus strengthening bone structure and reducing fracture risk.

Dosage and Administration:

• Use one spray (200 IU) intranasally once daily.
• Alternate nostrils daily – for example:
  • Day 1: Left nostril
  • Day 2: Right nostril
  • Continue alternating nostrils
• Before use:
  • Gently blow your nose to clear the nostrils.
  • Keep one nostril closed, insert the spray in the other, and sniff deeply while spraying.
  • Do not lie down immediately after application.
• Each bottle delivers 30 metered doses. Discard after 30 days from first use.

Storage Instructions

• Before opening: Store in refrigerator between 2°C and 8°C. Do not freeze.
• After opening: Store at room temperature (15°C–30°C). Use within 30 days.

Side Effects of Ostospray:

Common Side Effects

• Runny nose
• Nasal irritation (itching, burning, discomfort)
• Nosebleeds
• Headache
• Joint or back pain

Rare but Serious Effects – Seek Immediate Medical Attention

• Severe nasal irritation or persistent nosebleeds
• Allergic reaction: rash, swelling, difficulty breathing
• Hypocalcemia (low blood calcium levels) presenting as:
  • Numbness or tingling around the mouth or in fingers/toes
  • Muscle cramps or spasms

Precautions:

• Ensure adequate calcium and vitamin D intake throughout treatment.
• Inform your doctor if you have a history of allergic rhinitis, nasal infections, or recent nasal surgery.
• Monitor calcium levels regularly, especially in patients with hypocalcemia risk.
• Consult your doctor before starting if you have existing kidney, liver, or heart disease.

Safety Advice:

Missed Dose?

If you miss a dose, take it as soon as remembered. If it’s near the time of the next dose, skip the missed dose. Do not double the dose.

FAQs:

Does Ostospray increase bone density?

Yes. It slows down bone resorption and in some cases stimulates bone formation, leading to increased bone density.

Can Ostospray cause calcium deficiency?

Yes, hypocalcemia is a possible side effect. Symptoms may include tingling in extremities or around the mouth. Monitor calcium levels periodically during treatment.

How long does one bottle of Ostospray last?

Each bottle is pre-calibrated for 30 metered doses. It lasts for 30 days with once-daily use. Discard after this period even if some medicine remains.

Is it safe for pregnant or breastfeeding women?

Use during pregnancy or breastfeeding is not recommended unless clearly needed. Discuss with your physician before use.

How is Ostospray different from tablets for osteoporosis?

Ostospray is a nasal spray formulation of calcitonin, ideal for those who cannot tolerate oral bisphosphonates. It avoids gastrointestinal side effects common with tablets and provides direct nasal absorption for systemic effect.