Lioresal 25 Tablet – High-Strength Muscle Relaxant

Lioresal 25 Tablet is a centrally acting muscle relaxant used for the management of severe muscular symptoms such as stiffness, rigidity, and spasms caused by neurological disorders like multiple sclerosis, cerebral palsy, motor neuron disease, or injuries to the brain or spinal cord.

Uses of Lioresal 25 Tablet:

• Relief of muscle spasticity and rigidity
• Improvement in muscle movement and coordination

Benefits of Lioresal 25 Tablet:

Lioresal 25 Tablet contains Baclofen as its active ingredient. It alleviates muscular symptoms by acting on the spinal cord and brain to block overactive nerve signals that cause muscle contractions. This results in reduced muscle stiffness and pain, thereby enhancing mobility and daily function.

How Lioresal 25 Tablet Works?

Baclofen, a GABA-B receptor agonist, suppresses excessive neurotransmitter release in the spinal cord, leading to muscle relaxation without significantly compromising muscle strength.

Dosage and Administration:

• Take this medicine as directed by your physician.
• Swallow the tablet whole with water. Do not chew, break, or crush.
• Best taken with food or milk to reduce stomach upset.
• For nighttime spasms, take the tablet 1 hour before sleep or prior to activities like physiotherapy or bathing.

Missed Dose?

If a dose is missed, take it as soon as you remember. If it’s close to the next scheduled dose, skip the missed dose. Do not double the dose.

Common Side Effects:

Most side effects are mild and temporary. Contact your doctor if they persist or worsen.

• Drowsiness
• Dizziness
• Weakness
• Fatigue
• Nausea
• Constipation
• Headache
• Sedation
• Hypotension (low blood pressure)
• Hypotonia (reduced muscle tone)
• Convulsions
• Agitation
• Urinary retention
• Chills
• Increased white blood cell count

Safety Advice:

Condition	Precaution
Alcohol	UNSAFE – May increase drowsiness and CNS depression.
Pregnancy	CONSULT YOUR DOCTOR – Animal studies show risk. Use only if benefits outweigh risks.
Breastfeeding	SAFE IF PRESCRIBED – Minimal secretion into breast milk; generally safe.
Driving	UNSAFE – May cause sedation, dizziness, and blurred vision.
Kidney Disease	CAUTION – Dose adjustment required. Monitor for urinary issues.
Liver Disease	CAUTION – May increase liver enzymes. Regular monitoring advised.

Drug Interactions:

Concomitant use with certain medicines may enhance side effects. Inform your doctor if you are using any of the following:

Medicine	Interaction
Trihexyphenidyl	May cause dry mouth, blurred vision, constipation, and confusion.
Tramadol	May increase sedation and risk of respiratory depression.
Alfuzosin / Amlodipine / Atenolol	May lead to hypotension, dizziness, nausea, and fainting.

FAQs:

Can Lioresal 25 Tablet cause drowsiness?

Yes. It may cause significant sleepiness and dizziness. Avoid operating machinery or driving until you understand its effects on your body.

Can it be used for anxiety?

It is not officially approved for anxiety, but some evidence suggests it may help reduce post-traumatic stress symptoms.

Is it safe for liver patients?

Use with caution. Regular liver enzyme tests may be needed. Always consult your doctor before starting or continuing the medication.

What effect does it have on kidneys?

Lioresal 25 may cause urinary symptoms. Lower doses are recommended for patients with kidney issues or those on dialysis.

When is the best time to take Lioresal 25 Tablet?

Take with meals to avoid nausea. For night cramps, take at bedtime or 1 hour before specific muscle-use activities.