6-MP 50mg Tablet (Mercaptopurine) – Treatment for Blood Cancer (Leukemia)

6-MP 50mg Tablet contains mercaptopurine, a chemotherapy drug used to treat various types of blood cancers (leukemia) including acute lymphoblastic leukemia (ALL). As a purine antagonist, it interferes with cancer cell DNA/RNA synthesis, slowing tumor growth. This oral medication can be taken with or without food, though consistent timing is recommended. Patients require regular blood tests to monitor for bone marrow suppression and liver toxicity. While effective, it may cause gastrointestinal side effects and increased infection risk due to lowered blood cell counts.

Uses of 6-MP 50mg Tablet:

Treatment of acute lymphoblastic leukemia (ALL) in children and adults
Maintenance therapy for acute myeloid leukemia (AML)
May be used in autoimmune disorders (off-label)

Benefits of 6-MP 50mg Tablet:

6-MP 50mg Tablet is a cornerstone of ALL maintenance therapy, significantly improving long-term remission rates. Its oral administration allows convenient home treatment compared to IV chemotherapy. When used properly with monitoring, it effectively maintains remission while being generally better tolerated than many other chemotherapeutic agents. The drug’s targeted action on rapidly dividing cells helps spare some healthy tissues.

Side Effects of 6-MP 50mg Tablet:

Common side effects (affecting >10% patients):
– Nausea – Vomiting – Loss of appetite
– Diarrhea – Mild rash – Fatigue
Serious risks requiring medical attention:
– Severe bone marrow suppression – Liver toxicity
– Pancreatitis – Intestinal ulcers

How to Use?

Take once daily, preferably at the same time each day. Can be taken with or without food, but consistency is important. The typical dose ranges from 50-75mg/m² body surface area. Swallow whole with water – never crush or chew. Your oncologist will determine the exact dosage based on blood counts and treatment response.

How Medicine Works?

6-MP 50mg Tablet works through multiple mechanisms:

Converts to active metabolites that inhibit purine synthesis
Incorporates into DNA/RNA as false building blocks
Blocks de novo purine nucleotide formation

These actions preferentially affect rapidly dividing leukemia cells, disrupting their growth and replication.

Safety Advice

Blood monitoring: Weekly CBC initially, then monthly
Liver function: Regular LFTs required
TPMT testing: Recommended before starting (genetic test)
Pregnancy: Absolute contraindication
Vaccinations: Avoid live vaccines during treatment
Drug interactions: Many significant interactions

What If You Missed a Dose?

If you miss a dose, take it as soon as remembered unless it’s almost time for the next dose. Never double dose to compensate. If vomiting occurs shortly after taking, consult your doctor about whether to repeat the dose.

FAQs:

Q1: Why is TPMT testing important before starting 6-MP?

TPMT enzyme metabolizes it. About 10% of people have reduced activity and need lower doses to avoid severe toxicity. Testing helps personalize your dosage.

Q2: Can I take allopurinol with 6-MP?

No. Allopurinol increases 6-MP toxicity by inhibiting its breakdown. If co-administered, your 6-MP dose must be reduced by 75%.

Q3: How long will I need to take 6-MP?

For ALL maintenance, treatment typically continues for 2-3 years. The exact duration depends on your cancer type, response, and tolerance to therapy.

Q4: What foods should I avoid during treatment?

No specific dietary restrictions, but maintain good nutrition to help manage side effects. Avoid grapefruit which may affect drug metabolism. Stay well-hydrated.

Q5: Why do I need weekly blood tests?

6-MP can cause life-threatening bone marrow suppression. Regular CBCs help detect low blood counts early before complications develop.

Q6: Can I drink alcohol while on 6-MP?

Alcohol may increase liver toxicity risk. Complete avoidance is recommended given 6-MP’s existing hepatotoxicity potential.

Q7: What symptoms indicate liver problems?

Report immediately:
– Yellow skin/eyes – Dark urine – Severe nausea
– Right upper abdominal pain – Unusual bleeding/bruising

Q8: Can I get vaccinated during treatment?

Avoid live vaccines (MMR, varicella). Inactivated vaccines (flu shot) are generally safe but may be less effective. Always consult your oncologist first.