Aromasin 25mg Tablet (Exemestane) – Aromatase Inhibitor for Breast Cancer Treatment

Aromasin 25mg Tablet contains exemestane, a steroidal aromatase inhibitor used to treat hormone receptor-positive breast cancer in postmenopausal women. This medication works by permanently binding to and inactivating the aromatase enzyme, dramatically reducing estrogen production throughout the body. Aromasin is particularly effective as adjuvant therapy following 2-3 years of tamoxifen treatment, helping prevent cancer recurrence. Patients should take this tablet with food once daily for optimal absorption. A patient assistance program is available in India through Tata 1mg (1800-102-1618) for eligible patients.

Uses of Aromasin 25mg Tablet:

Adjuvant treatment of early-stage breast cancer after initial tamoxifen therapy
First-line therapy for advanced or metastatic breast cancer
Prevention of cancer recurrence in high-risk postmenopausal women
Treatment of estrogen-dependent tumors

Benefits of Aromasin 25mg Tablet:

Aromasin 25mg Tablet demonstrates superior efficacy with 32% reduced recurrence risk compared to continuing tamoxifen in clinical trials. As an irreversible steroidal inhibitor, it provides consistent estrogen suppression without developing resistance. Patients benefit from convenient once-daily oral administration and generally better tolerance than chemotherapy, with most side effects being manageable.

Side Effects of Aromasin 25mg Tablet:

Common effects (affecting >10% patients):
– Hot flashes (21%) – Fatigue (16%) – Joint pain (15%)
– Headache (13%) – Insomnia (11%) – Increased sweating (10%)
Serious risks requiring monitoring:
– Osteoporosis and fractures – Cardiovascular effects
– Liver function abnormalities – Depression

How to Use Aromasin Tablet?

Take 1 tablet (25mg) daily after a meal, preferably at the same time each day. Swallow whole with water – do not crush or chew. Continue for the full prescribed duration (typically 2-5 years total hormonal therapy) unless directed otherwise by your oncologist. Regular bone density scans are recommended during treatment.

How Aromasin Tablet Works?

Aromasin 25mg Tablet is an irreversible steroidal aromatase inhibitor that:

Permanently binds to the aromatase enzyme
Blocks conversion of androgens to estrogens in all tissues
Reduces circulating estrogen by >90% in postmenopausal women
Creates “suicidal inhibition” – permanently deactivates the enzyme

This action deprives estrogen-dependent cancer cells of their growth stimulus.

Safety Advice:

Bone health: Supplement with calcium/vitamin D; monitor bone density annually
Pregnancy: Absolute contraindication – use effective contraception
Liver function: Regular monitoring required (avoid in severe impairment)
Drug interactions: Avoid estrogen products and strong CYP3A4 inducers
Mental health: Monitor for depression or mood changes

What If You Miss a Dose?

Take the missed dose as soon as remembered unless it’s nearly time for the next dose. Never take two doses together to compensate. If vomiting occurs shortly after taking, consult your doctor about whether to repeat the dose.

FAQs:

Q1: Why must Aromasin be taken with food?

Food increases absorption by 40%. Taking without food may reduce effectiveness. A meal containing fat is ideal for optimal drug levels.

Q2: How does Aromasin differ from other aromatase inhibitors?

Unlike non-steroidal inhibitors, Aromasin permanently deactivates the aromatase enzyme, providing consistent suppression without developing resistance.

Q3: Can premenopausal women use Aromasin?

No. Aromasin is only for postmenopausal women as active ovaries produce too much estrogen for effective suppression.

Q4: How to manage joint pain from Aromasin?

Regular low-impact exercise, omega-3 supplements, and acetaminophen may help. For severe cases, your doctor may recommend physical therapy or temporary treatment breaks.