Azel 40mg Capsule (Enzalutamide) – Antiandrogen for Prostate Cancer Treatment

Azel 40mg Capsule contains enzalutamide, a second-generation antiandrogen used to treat metastatic castration-resistant prostate cancer. It works by blocking testosterone effects at multiple levels – preventing androgen receptor binding, nuclear translocation, and DNA interaction. This comprehensive action helps slow cancer progression even when traditional hormone therapy fails. Patients typically take one capsule daily, with or without food, though consistent timing is recommended. While effective, it requires monitoring for potential side effects including cardiovascular risks and seizures.

Uses of Azel 40mg Capsule:

• Treatment of metastatic castration-resistant prostate cancer (mCRPC)
• Therapy for non-metastatic castration-resistant prostate cancer at high risk of spread
• May be used in combination with androgen deprivation therapy

Benefits of Azel 40mg Capsule:

Azel 40mg Capsule demonstrates superior efficacy with median survival extension of 4.8 months in clinical trials compared to placebo. Its triple mechanism of action provides more complete androgen blockade than first-generation antiandrogens. Patients benefit from convenient oral administration and delayed disease progression, including reduced incidence of painful bone metastases.

Side Effects of Azel 40mg Capsule:

Very common side effects (>30% incidence):
– Hot flashes – Fatigue – Headache
– Hypertension – Falls – Musculoskeletal pain
Serious risks requiring monitoring:
– Seizures – Cardiovascular events – Posterior reversible encephalopathy syndrome (PRES)

How to Use Azel Capsule?

Take 1 capsule (40mg) once daily, with or without food, at approximately the same time each day. Swallow whole with water – do not open or crush the capsule. Your doctor may adjust the dose based on tolerability and response. Continue treatment until disease progression or unacceptable toxicity occurs.

How Azel Capsule Works?

Azel 40mg Capsule provides comprehensive androgen receptor blockade through:

1. Competitive inhibition of androgen binding
2. Prevention of nuclear translocation
3. Interference with DNA binding
4. Induction of receptor degradation

This multi-target action helps overcome resistance seen with first-generation antiandrogens.

Safety Advice:

• Seizure risk: Contraindicated in patients with seizure history
• Cardiac monitoring: Regular blood pressure and ECG checks
• Pregnancy: Absolute contraindication – may cause fetal harm
• Hepatic function: Regular LFT monitoring required
• Drug interactions: Many significant CYP interactions
• Sun protection: Increased photosensitivity risk

What If You Miss a Dose?

Take the missed dose as soon as remembered unless it’s within 12 hours of the next dose. Never take extra capsules to compensate. If vomiting occurs shortly after taking, do not repeat the dose – continue with the next scheduled dose.

FAQs:

Q1: How long does Azel take to work?

PSA levels typically begin dropping within 4-8 weeks, with clinical response (pain relief, improved symptoms) often following within 2-3 months. Your doctor will monitor progress through regular PSA tests and imaging.

Q2: Can I take painkillers with Azel?

Most NSAIDs are safe if liver function is normal. Avoid St. John’s Wort and other CYP3A4 inducers. Always inform your doctor about all medications/supplements you’re taking.

Q3: Why must I avoid grapefruit?

Grapefruit inhibits CYP3A4 enzymes that metabolize Azel, potentially increasing drug levels and side effects. Avoid grapefruit products during treatment.

Q4: How to manage hot flashes?

Dress in layers, avoid triggers like spicy foods, and stay cool. Your doctor may prescribe low-dose antidepressants if severe. About 30% of patients experience improvement after 3-6 months.

Q5: Can I continue driving while on Azel?

Use caution – Azel may cause dizziness/fatigue. Avoid driving if you experience these symptoms. The risk is higher when starting treatment or after dose increases.

Q6: What blood tests are needed?

Regular monitoring includes:
– PSA levels
– Liver function tests
– Complete blood count
– Blood pressure checks

Q7: Does Azel affect sexual function?

Yes, like all antiandrogens, Azel typically causes loss of libido and erectile dysfunction. Discuss management options with your doctor.

Q8: What symptoms indicate serious side effects?

Seek immediate care for:
– Seizures – Severe headache/confusion
– Chest pain – Shortness of breath
– Vision changes – Severe skin reactions