Aziderm 20% Cream (Azelaic Acid) – Prescription-Strength Acne Treatment

Aziderm 20% Cream is a high-potency dermatological formulation containing azelaic acid, specifically developed for treating moderate to severe acne vulgaris. This prescription-strength cream effectively combats inflammatory acne lesions, including painful lumps, redness, and swelling. As a multi-action treatment, it not only kills acne-causing bacteria but also helps prevent post-acne scarring and hyperpigmentation. The cream formulation makes it suitable for various skin types, including those prone to dryness. For optimal results, apply to clean, dry skin as directed by your dermatologist. While initial improvements may be visible within 2-4 weeks, complete clearance typically requires 3-6 months of consistent use. Avoid application on eczema, sunburned skin, or open wounds.

Uses of Aziderm 20% Cream:

This medication is clinically approved for:

• Treatment of inflammatory acne vulgaris
• Management of comedonal acne (blackheads/whiteheads)
• Reduction of post-acne hyperpigmentation
• Adjunctive treatment of rosacea (under medical supervision)

Benefits of Aziderm 20% Cream:

Patients experience multiple therapeutic benefits:

• Strong antibacterial action against P. acnes bacteria
• Dual exfoliating action (surface and within pores)
• Anti-inflammatory properties reduce redness and swelling
• Helps normalize skin pigmentation
• Cream base provides moisturization while treating acne
• Prevents formation of new acne lesions with continued use

Side Effects of Aziderm 20% Cream:

Common but typically transient side effects include:

• Initial burning or stinging sensation (usually subsides in 10-15 minutes)
• Mild skin irritation or redness
• Temporary itching or tingling
• Dryness or slight peeling (manageable with moisturizer)

These effects generally diminish within 2-3 weeks as skin acclimates. Consult your dermatologist if persistent.

How to Use Aziderm 20% Cream?

Step-by-Step Application:

1. Cleanse skin with pH-balanced cleanser and pat dry
2. Apply a thin layer (pea-sized amount for full face) to affected areas
3. Gently massage until fully absorbed
4. Begin with once-daily application (evening) for first week if sensitive skin
5. Gradually increase to twice daily (morning and evening) as tolerated
6. Wait 5 minutes before applying moisturizer/sunscreen

How Aziderm 20% Cream Works?

The therapeutic action occurs through multiple pathways:

• Antimicrobial: Bactericidal against P. acnes and S. epidermidis
• Keratolytic: Normalizes abnormal keratinization process
• Anti-inflammatory: Reduces cytokine production and free radicals
• Depigmenting: Inhibits tyrosinase activity in hyperactive melanocytes

Safety Advice:

• Pregnancy: Category B – Generally safe when prescribed
• Breastfeeding: Minimal systemic absorption; likely safe
• Sun Exposure: Use broad-spectrum SPF 30+ daily
• Other Topicals: Avoid combining with harsh exfoliants unless directed
• Eye Area: Strictly avoid contact with eyes and mucous membranes

What If You Miss a Dose?

Apply as soon as remembered if within a few hours. If close to next dose time, skip the missed application. Never apply double quantity to compensate.

FAQs:

Q1. How does Aziderm 20% Cream differ from the 10% formulation?

The 20% concentration provides enhanced efficacy for stubborn, inflammatory acne but may cause more initial irritation. The 10% is better suited for mild acne or sensitive skin.

Q2. Can I use Aziderm 20% Cream with my regular moisturizer?

Yes, but wait 10-15 minutes after application. Choose oil-free, non-comedogenic moisturizers labeled “for acne-prone skin.”

Q3. Why does my skin tingle after application?

Temporary tingling is normal as the active penetrates. This usually subsides within 2 weeks. If severe burning occurs, reduce frequency and consult your doctor.

Q4. How long until I see significant improvement?

Most patients notice: 20-30% improvement by week 4, 50% by week 8, and 75%+ by week 12 with consistent use.

Q5. Can this cream help with acne scars?

While not specifically for scars, early use prevents post-inflammatory hyperpigmentation. For existing scars, combine with other treatments as advised by your dermatologist.

Q6. Should I stop using if my acne flares initially?

Mild “purging” (temporary worsening) is common in first 2-4 weeks as deep clogs surface. Continue use unless severe irritation develops.

Q7. Is prescription required for Aziderm 20% Cream?

Yes, this higher concentration requires medical supervision unlike some OTC acne treatments.