Biovorin Injection – Folic Acid Support for Methotrexate Therapy

Biovorin Injection is a prescription medication primarily used to prevent the harmful effects of methotrexate chemotherapy and to treat cases of methotrexate overdose. It is also indicated in the treatment of megaloblastic anemia caused by folic acid deficiency, particularly when oral supplementation is not feasible. Biovorin Injection contains Leucovorin Calcium, a form of folic acid that plays a crucial role in DNA synthesis and cellular protection.

Uses of Biovorin Injection:

• Counteracts the toxic effects of high-dose methotrexate treatment
• Treats accidental methotrexate overdose
• Manages megaloblastic anemia due to folate deficiency

How Biovorin Injection Works?

Biovorin acts as a folic acid analog that bypasses methotrexate-induced folate inhibition, restoring normal DNA, RNA, and protein synthesis in healthy cells. This makes it an essential rescue therapy in methotrexate-based cancer treatments.

Dosage and Administration:

This medicine is administered as a slow intravenous (IV) injection under the supervision of a healthcare provider. The dosage depends on:

• The amount and timing of methotrexate administered
• Your kidney function
• Serum methotrexate concentration levels

Note: Do not self-administer. Always follow your doctor’s instructions carefully.

Side Effects of Biovorin Injection:

Like all medications, it may cause side effects, though not everyone experiences them. The most common side effects include:

• Injection site pain
• Redness or swelling at the injection site

Contact your doctor if side effects persist or worsen.

Precautions & Safety Advice:

Alcohol

Consult your doctor before consuming alcohol during treatment.

Pregnancy

It may not be safe during pregnancy. Use only if clearly prescribed by a healthcare provider after assessing the risks and benefits.

Breastfeeding

There is limited information on the safety of Biovorin during breastfeeding. Consult your doctor before use.

Driving

This medication typically does not affect your ability to drive or operate machinery.

Kidney & Liver Impairment

Use with caution in patients with kidney or liver disorders. Dose adjustment may be required. Regular monitoring is advised.

What To Do If You Miss a Dose?

If you miss a dose of the Injection, inform your doctor. If it’s close to the next scheduled dose, skip the missed dose—do not double the dose.

Laboratory Monitoring During Therapy:

• Serum methotrexate levels
• Complete blood count (CBC)
• Serum calcium levels

Important Tips During Methotrexate Detoxification:

• Maintain urine output above 2,500 mL/24 hours with oral or IV fluids
• Ensure urine pH is above 7.0 by alkalinizing agents if required
• Avoid acidic foods, drinks, or drugs that lower urinary pH

Frequently Asked Questions (FAQs):

What is Biovorin Injection used for?

It is used to prevent or treat the toxic side effects of methotrexate and to manage megaloblastic anemia when oral folic acid isn’t effective or feasible.

How quickly does it work?

The Injection starts working within 5 minutes of IV administration, depending on the dose and patient condition.

Can I take Biovorin Injection during pregnancy?

Not usually recommended. Use only under strict medical guidance.

Does Biovorin Injection affect blood tests?

Yes. Regular blood and calcium level monitoring is required to adjust the dosage and avoid complications such as hypercalcemia.

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