Bosuvi Tablet – Targeted Therapy for Chronic Myeloid Leukemia & Other Cancers

Bosuvi Tablet is a prescription anticancer medication primarily used in the treatment of Chronic Myeloid Leukemia (CML), a type of blood cancer. It belongs to a class of drugs known as tyrosine kinase inhibitors, which work by blocking abnormal proteins that signal cancer cells to grow. This helps slow or stop the progression of cancer.

Uses of Bosuvi Tablet:

Bosuvi is indicated in the treatment of various cancers, including:

• Chronic Myeloid Leukemia (CML)
• Pancreatic cancer
• Kidney cancer
• Liver cancer
• Thyroid cancer
• Breast cancer
• Colon and rectal cancer
• Non-small cell and small cell lung cancer
• Gastrointestinal stromal tumors
• Soft tissue sarcoma
• Chronic idiopathic myelofibrosis

How Bosuvi Tablet Works?

Bosuvi blocks specific proteins (BCR-ABL tyrosine kinases) involved in cancer cell growth. By targeting these proteins, it helps prevent the multiplication of cancer cells and slows disease progression, especially in chronic myeloid leukemia and other tumors driven by tyrosine kinase overactivity.

How to Use Bosuvi Tablet?

• Take exactly as prescribed by your doctor.
• Swallow the tablet whole with water.
• May be taken with or without food.
• Take at the same time each day for best results.

Missed Dose?

If you miss a dose, skip it and continue with your next scheduled dose. Do not double the dose to make up for the missed one.

Common Side Effects of Bosuvi Tablet:

Most side effects are manageable and may subside as your body adapts:

• Nausea, vomiting, and diarrhea
• Abdominal pain
• Headache
• Respiratory tract infections
• Cough and breathlessness
• Low blood cell counts (white cells, red cells, platelets)
• Fatigue
• Increased liver enzymes
• Nasopharyngitis

Seek immediate medical help if you experience vision changes, hearing loss, severe headache, chest pain, leg swelling, or irregular heartbeat.

Drug Interactions:

Do not use Bosuvi with the following medications:

• Domperidone – Life-threatening heart rhythm issues
• Tetrabenazine – Risk of fatal arrhythmia
• Ondansetron (oral/injection) – Serious cardiac risk
• Hydroxyzine – May alter heart rhythm fatally

Safety Advice:

Alcohol

Consult your doctor. Interaction with alcohol is not well-studied.

Pregnancy

Unsafe during pregnancy. It may cause harm to the unborn baby. Use effective contraception and avoid pregnancy during and up to 3 months after treatment.

Breastfeeding

Not recommended. Bosuvi may pass into breast milk and harm the infant.

Driving

May affect alertness or cause dizziness. Avoid driving if you experience such symptoms.

Kidney & Liver Disease

Use with caution. Dosage adjustment may be necessary. Inform your doctor if you have a history of kidney or liver issues.

Precautions During Treatment:

• Avoid contact with people who are sick or have infections.
• Use soft toothbrushes and avoid sharp instruments to reduce bleeding risk.
• Maintain hygiene and monitor temperature regularly.
• Use moisturizers and SPF sunscreen to manage dry skin and photosensitivity.

Managing Side Effects:

Constipation

Eat fiber-rich food, stay hydrated, and consider a prescribed stool softener.

Hair Loss or Changes

Temporary hair thinning or brittleness may occur. Use gentle hair care products and avoid heat styling.

Taste Changes

Use salt/baking soda mouth rinses. Add herbs and flavorings to enhance food appeal.

Fatigue

Rest well, eat nutritious food, and engage in light exercise if possible.

Numbness or Tingling

Report symptoms like numbness or burning in limbs. Your dose may need adjustment.

Frequently Asked Questions (FAQs):

How do I know Bosuvi Tablet is working?

Your doctor will monitor your progress with regular blood tests and imaging scans to determine if the cancer is responding.

Can Bosuvi Tablet cause serious lung problems?

Yes. Rare but serious lung issues can occur. Seek immediate help for dry cough, breathing difficulties, or chest pain.

Can I take Bosuvi Tablet during pregnancy?

No. It is harmful to the fetus. Use effective birth control during treatment and consult your doctor.

What should I do to avoid infections?

Limit exposure to crowds, wash hands often, and monitor for fever or sore throat. Seek medical attention if symptoms arise.

Does Bosuvi Tablet affect fertility?

Yes, Bosuvi may affect fertility. Discuss fertility preservation options with your doctor before starting treatment.

Can I stop taking Bosuvi Tablet if I feel better?

No. Always complete the course as prescribed. Discontinuing early can lead to cancer progression.

Storage Instructions:

• Store in a cool, dry place away from direct sunlight.
• Keep out of reach of children and pets.
• Do not use after the expiry date printed on the packaging.