Cyclophil ME 100 Capsule (Cyclosporine) – Immunosuppressant for Organ Transplants & Autoimmune Disorders

Cyclophil ME 100 Capsule is a high-dose immunosuppressant medication crucial for preventing organ rejection in patients who have undergone liver, kidney, heart, or bone marrow transplants. This cyclosporine-based formulation works by carefully modulating the immune system to prevent it from attacking transplanted organs. Additionally, it serves as an effective treatment for severe rheumatoid arthritis, nephrotic syndrome, and psoriasis. The 100mg strength requires precise dosage calculation by your physician based on your weight, medical condition, and treatment response. Consistent daily administration at the same time is vital for maintaining stable drug levels in your system. Long-term therapy is typically necessary, even when symptoms improve, to ensure transplant success and prevent disease flare-ups.

Uses of Cyclophil ME 100 Capsule:

• Prevention of organ rejection in transplant patients (liver, kidney, heart, bone marrow)
• Management of severe rheumatoid arthritis
• Treatment of nephrotic syndrome
• Control of moderate-to-severe psoriasis
• Post-bone marrow transplantation care

Benefits of Cyclophil ME 100 Capsule:

• Transplant Protection: Significantly reduces risk of organ rejection
• Autoimmune Regulation: Controls overactive immune responses in autoimmune disorders
• Dual-Action Formula: Addresses both transplant needs and autoimmune conditions
• Precision Dosing: 100mg strength allows for tailored immunosuppression

Side Effects of Cyclophil ME 100 Capsule:

• Headache (common)
• Hypertrichosis (excessive hair growth)
• Hypertension (high blood pressure)
• Gastrointestinal disturbances (nausea, diarrhea)
• Gingival hyperplasia (gum overgrowth)
• Tremors or shaking
• Increased susceptibility to infections
• Potential kidney function changes
• Elevated risk of skin malignancies

How to Use Cyclophil ME 100 Capsule?

Take this medication exactly as prescribed by your transplant specialist or rheumatologist. The 100mg capsule can be taken with or without food, but maintaining a strict schedule is essential. Swallow the capsule whole with water – do not break, crush, or chew. Your doctor will regularly monitor your blood levels to adjust dosage as needed.

How Cyclophil ME 100 Capsule Works?

It contains cyclosporine, which selectively inhibits calcineurin in T-lymphocytes. This action blocks interleukin-2 production, a key cytokine in immune response activation. For transplant patients, this prevents cytotoxic T-cells from attacking the new organ. In autoimmune conditions, it reduces pathological immune activity that causes joint inflammation (arthritis) or excessive skin cell turnover (psoriasis).

Safety Advice:

• Alcohol: No direct interaction, but moderation advised
• Pregnancy: Category C – use only if potential benefit justifies risk
• Breastfeeding: Contraindicated due to infant risk
• Driving: Caution advised if experiencing tremors
• Renal Impairment: Requires dosage adjustment and monitoring
• Hepatic Dysfunction: Needs careful dose titration
• Sun Protection: Mandatory due to photosensitivity risk

What If You Miss a Dose?

If you forget a dose, take it as soon as remembered unless it’s nearly time for the next dose. Never take two doses together. Maintain your regular schedule thereafter. Inform your healthcare team about any missed doses during follow-ups.

Important Drug Interactions:

It has significant interactions with:

• All statins (increased risk of rhabdomyolysis)
• Potassium-sparing diuretics (hyperkalemia risk)
• Live vaccines (avoid completely)
• NSAIDs (increased nephrotoxicity)
• Antifungals (increased cyclosporine levels)

FAQs:

Q1. How does the 100mg dose differ from lower strengths?

The 100mg capsule allows for higher dosing when needed while reducing pill burden. However, it requires the same careful monitoring as lower doses.

Q2. Can I take this with grapefruit juice?

No, grapefruit increases cyclosporine absorption unpredictably, potentially leading to toxicity.

Q3. Why is frequent blood testing necessary?

Regular therapeutic drug monitoring ensures your levels stay in the effective but safe range, preventing both rejection and toxicity.

Q4. How should I handle increased hair growth?

This common side effect is usually manageable with cosmetic methods and typically reverses after treatment ends.

Q5. What emergency symptoms should prompt immediate medical attention?

Seek help for: severe headaches, vision changes, seizures, breathing difficulties, or signs of serious infection.

Q6. Can I receive routine vaccinations while on this medication?

Inactivated vaccines are generally safe but live vaccines are contraindicated. Always consult your doctor first.