Estraval Depot Injection (Estradiol Valerate) – Hormone Replacement Therapy (HRT)

Estraval Depot Injection contains estradiol valerate, a synthetic estrogen hormone used in Hormone Replacement Therapy (HRT). This injectable medicine acts as a natural estrogen substitute, essential for maintaining fertility, bone health, and female sexual characteristics. It is prescribed for menopausal symptoms (hot flashes, vaginal dryness), postmenopausal osteoporosis, prostate cancer (as adjunct therapy), and gender-affirming hormone therapy. Available in sterile oil solution form, it is administered intramuscularly every 2–4 weeks under medical supervision.

Uses of Estraval Depot Injection:

• Hormone Replacement Therapy (HRT): Replenishes estrogen levels in menopausal women or those with ovarian failure.
• Postmenopausal Osteoporosis: Prevents bone density loss.
• Prostate Cancer (Supportive Treatment): Used alongside primary therapies in males.
• Gender-Affirming Therapy: Induces female secondary sexual characteristics in transgender women.

Benefits of Estraval Depot Injection:

• Relieves menopausal symptoms (hot flashes, vaginal dryness).
• Reduces risk of osteoporosis in postmenopausal women.
• Supports prostate cancer treatment.
• Facilitates smooth hormonal transition in gender-affirming therapy.

Side Effects of Estraval Depot Injection:

Common side effects:

• Swelling in hands/feet, nausea, vaginal bleeding, mood changes.
• Headaches, breast tenderness, skin rashes.

Serious side effects (seek medical help):

• Yellow skin/eyes (jaundice), chest pain, severe abdominal pain.
• Blood clots, vision changes, memory loss, liver dysfunction.

How to Use Estraval Depot Injection?

• Administered intramuscularly every 2–4 weeks (as prescribed).
• Check for discoloration/particles before injection. Do not use if present.
• Store at 15–25°C; avoid freezing or excessive humidity.

How Estraval Depot Injection Works?

Estradiol valerate binds to estrogen receptors, mimicking natural estrogen. It gradually restores hormonal balance, alleviating menopausal symptoms and supporting bone/sexual health.

Safety Advice:

• Avoid if allergic to estradiol valerate.
• Inform your doctor about cancer history, diabetes, or blood clots.
• Do not smoke; increases clotting risk.
• Limit sun exposure (may cause skin pigmentation).

What If You Missed a Dose?

Inject as soon as remembered. If close to the next dose, skip the missed one. Do not double dose.

FAQs:

Q1. How often is Estraval Depot Injection administered?

Typically every 2–4 weeks, depending on the condition.

Q2. Can it be used for transgender hormone therapy?

Yes, under medical supervision to induce feminine traits.

Q3. Does it increase cancer risk?

Prolonged use may raise breast/endometrial cancer risk. Regular checkups are advised.

Q4. Can I self-administer this injection?

Only if trained. Otherwise, consult a healthcare provider.

Q5. What if the liquid appears cloudy?

Do not use. Discard and get a new vial.