Pletoz 100 Tablet – Cilostazol for Intermittent Claudication

Pletoz 100 Tablet contains Cilostazol (100 mg), a phosphodiesterase type 3 (PDE3) inhibitor used for improving blood flow in patients suffering from intermittent claudication, a condition caused by reduced blood supply to the legs. It helps reduce symptoms like leg pain, cramping, numbness, and fatigue during walking.

Uses of Pletoz 100 Tablet:

• Treatment of Intermittent Claudication
• Peripheral Artery Disease (PAD) – improvement in walking distance and function

How Pletoz 100 Works?

Pletoz 100 Tablet acts by inhibiting phosphodiesterase III enzyme, resulting in vasodilation (widening of blood vessels) and inhibition of platelet aggregation. This improves blood flow, particularly to the lower limbs, and reduces the frequency and severity of leg pain while walking.

Dosage & Administration:

• Dose: As prescribed, usually 100 mg twice daily.
• When: On an empty stomach (30 minutes before or 2 hours after meals).
• Do not crush, chew, or break the tablet.

Common Side Effects:

• Headache
• Dizziness
• Palpitations / Increased heart rate
• Diarrhea
• Abdominal pain
• Abnormal stools
• Nasal inflammation
• Swelling (edema)
• Bleeding disorders

Serious Side Effects – Immediate Attention Required:

• Bleeding symptoms: bruises, bleeding gums, blood in stool/urine/vomit
• Severe dizziness or fainting
• Chest pain or shortness of breath (possible heart issues)

Safety Advice:

Condition	Safety
Alcohol	Consult your doctor. Interaction not established, but caution is advised.
Pregnancy	Not recommended. Animal studies show risk. Use only if necessary and prescribed.
Breastfeeding	Possibly unsafe. May pass into breast milk and harm the baby. Consult your doctor.
Driving	Unsafe. May cause dizziness or drowsiness. Avoid driving if affected.
Kidney	Safe if prescribed. No dose adjustment needed in mild to moderate kidney disease.
Liver	Use with caution. Limited data in moderate/severe liver impairment. Consult your doctor.

Drug Interactions – Avoid or Use with Caution:

Do NOT use with the following due to increased bleeding risk or adverse interaction:

• Pimozide – Risk of QT prolongation
• Streptokinase, Urokinase, Fondaparinux, Bemiparin – High bleeding risk

Monitor closely if used with: blood thinners (warfarin, aspirin), antihypertensives, or other antiplatelet drugs.

Precautions:

• Not recommended in patients with heart failure (any severity).
• Monitor blood pressure regularly; Pletoz may cause hypotension or rarely hypertension.
• Inform your doctor about any history of bleeding disorders or recent surgery.
• Stop 5 days before surgery to reduce bleeding risk.

Missed Dose?

If you miss a dose, take it as soon as you remember. If it’s nearly time for the next dose, skip the missed dose—do not double it.

FAQs:

1. Can Pletoz 100 Tablet increase bleeding?

Yes. Cilostazol reduces platelet aggregation, which increases the risk of bleeding. Be cautious during activities, and report any bleeding signs immediately.

2. When will I notice improvement in symptoms?

It may take 2–4 weeks for symptoms to start improving and up to 12 weeks for full benefits. Continue taking the medicine regularly as prescribed.

3. Should Pletoz 100 be stopped before surgery?

Yes. Stop 5 days prior to any surgical procedure to minimize bleeding complications. Always inform your doctor before any planned operation.

4. Is Pletoz 100 safe in heart failure?

No. Pletoz should be avoided in all patients with heart failure. It may worsen the condition and reduce survival.

5. Does Pletoz 100 increase or decrease blood pressure?

Usually, it lowers blood pressure due to vasodilation, but in some rare cases, an increase has been reported. Blood pressure should be monitored regularly.

6. Is Pletoz a blood thinner?

Pletoz is not a classical blood thinner but it inhibits platelet aggregation, making the blood less likely to form clots.