Resihance Tablet (Regorafenib) – Tyrosine Kinase Inhibitor for Colorectal Cancer Treatment

Resihance Tablet is a tyrosine kinase inhibitor medication used to treat colorectal cancer (cancer of the colon and rectum). It works by blocking multiple enzymes that promote cancer cell growth and blood vessel formation in tumors. This tablet should be taken with food at the same time each day for optimal absorption. While effective, it may cause side effects like high blood pressure, fatigue, and gastrointestinal issues. Regular blood tests are required to monitor liver function and blood cell counts during treatment. Patients should avoid pregnancy and discuss all current medications with their healthcare provider before starting therapy.

Uses of Resihance Tablet:

• Treatment of metastatic colorectal cancer
• Management of advanced gastrointestinal stromal tumors (GIST)
• Therapy for patients who have stopped responding to other cancer treatments

Benefits of Resihance Tablet:

Resihance Tablet helps slow tumor growth and prevent cancer spread in colorectal cancer patients. It targets multiple cancer growth pathways simultaneously, making it effective when other treatments fail. Clinical studies show it can improve progression-free survival in advanced cases. Patients should maintain hydration and avoid alcohol/smoking to maximize treatment benefits.

Side Effects of Resihance Tablet:

Very common side effects (affecting more than 1 in 10 people) include:
– Fatigue – Diarrhea – High blood pressure – Skin rash
– Decreased appetite – Mouth sores – Weight loss
Serious side effects requiring immediate medical attention:
– Severe bleeding – Heart problems – Liver toxicity – Severe skin reactions

How to Use Resihance Tablet?

Take as prescribed, typically once daily with a low-fat meal. Swallow tablets whole with water – do not crush or chew. Treatment usually continues until disease progression or unacceptable toxicity occurs. Your oncologist will determine the exact dosage schedule.

How Medicine Works?

Resihance Tablet contains regorafenib, which inhibits multiple kinase enzymes involved in:
1. Tumor angiogenesis (VEGFR1-3, TIE2)
2. Cancer cell signaling (KIT, RET, RAF1, BRAF)
3. Tumor microenvironment (PDGFR, FGFR)
This multi-target action helps block cancer cell proliferation and blood supply to tumors.

Safety Advice:

• Pregnancy: Absolutely contraindicated – causes fetal harm
• Breastfeeding: Discontinue nursing during treatment
• Liver function: Requires regular monitoring
• Blood pressure: Monitor weekly initially
• Bleeding risk: Avoid if recent bleeding events
• Drug interactions: Many significant interactions

What If You Missed a Dose?

If you miss a dose, take it as soon as you remember unless it’s within 12 hours of the next dose. Never take two doses at the same time. If you vomit after taking a dose, do not take an extra tablet.

FAQs:

Q1: Is Resihance Tablet a chemotherapy drug?

Yes, it’s classified as a targeted chemotherapy agent that specifically blocks cancer growth signals rather than broadly attacking dividing cells.

Q2: How long does it take to work?

Clinical response typically becomes evident within 6-8 weeks, though timing varies. Your doctor will monitor progress through scans and blood tests.

Q3: Why must I take it with food?

Food improves drug absorption by 48-73%. A low-fat meal is recommended to minimize variability in medication levels.

Q4: Can I take painkillers with this medication?

Avoid NSAIDs (ibuprofen, aspirin) due to bleeding risk. Acetaminophen may be used cautiously after consulting your doctor.

Q5: How will I know if it’s working?

Your oncologist will assess response through regular CT scans, tumor marker tests, and symptom evaluation – not by side effects.

Q6: What should I do about mouth sores?

Use saltwater rinses, avoid alcohol mouthwashes, and ask your doctor about magic mouthwash preparations. Severe cases may need dose adjustments.

Q7: Why do I need weekly blood pressure checks?

About 30% of patients develop treatment-related hypertension, usually within the first cycle. Early detection prevents complications.

Q8: Can I get vaccinated during treatment?

Live vaccines are contraindicated. Inactivated vaccines (flu shot) are generally safe but may be less effective – consult your oncologist.