Xovoltib 20mg Tablet is a tyrosine kinase inhibitor containing afatinib, specifically designed for treating EGFR mutation-positive non-small cell lung cancer (NSCLC). This targeted therapy works by precisely blocking epidermal growth factor receptors (EGFR) that drive cancer cell growth. Unlike traditional chemotherapy, Xovoltib selectively attacks cancer cells while sparing healthy cells, resulting in fewer systemic side effects. The 20mg dosage provides optimal therapeutic levels for most patients, though individual dosing may vary based on mutation type and treatment response. Patients typically take one tablet daily on an empty stomach, with treatment duration determined by ongoing response and tolerability.

Uses of Xovoltib 20mg Tablet:

• First-line treatment for metastatic NSCLC with EGFR exon 19 deletions or exon 21 (L858R) substitutions
• Therapy for squamous cell carcinoma of the lung progressing after platinum-based chemotherapy
• Management of NSCLC with uncommon EGFR mutations (G719X, L861Q, S768I)
• Treatment of NSCLC with HER2 mutations in certain cases

Benefits of Xovoltib 20mg Tablet:

• Targeted action against EGFR-driven cancers
• Proven to delay disease progression
• Oral administration for convenient home treatment
• Better tolerated than conventional chemotherapy
• Shown to improve quality of life measures

Side Effects of Xovoltib 20mg Tablet:

Very common (≥1/10 patients):
• Diarrhea (90% patients, usually grade 1-2)
• Rash/acne (80%, typically face/chest)
• Stomatitis (70%, mouth ulcers)
• Paronychia (nail inflammation, 60%)

Common (≥1/100 to <1/10):
• Decreased appetite
• Dry skin
• Nausea/vomiting
• Fatigue
Serious: Interstitial lung disease (2%), severe hepatotoxicity (0.5%)

How to Use Xovoltib 20mg Tablet?

• Timing: Take at same time daily, 1 hour before or 3 hours after food
• Administration: Swallow whole with water; may dissolve in water if needed
• Hydration: Maintain 2L daily fluid intake to manage diarrhea
• Skin care: Initiate moisturizing regimen from day 1
• Monitoring: Regular LFTs and clinical assessments required

How Xovoltib 20mg Tablet Works?

Xovoltib irreversibly binds to EGFR (ErbB1), HER2 (ErbB2), and HER4 (ErbB4) receptors, blocking tyrosine kinase autophosphorylation. This inhibits downstream signaling pathways (MAPK and PI3K-AKT) that promote cancer cell proliferation and survival. The irreversible binding provides sustained target inhibition even after plasma levels decline, offering continuous therapeutic effect between doses.

Safety Advice:

• Pregnancy: Category D – Absolute contraindication
• Contraception: Required for 2 months post-treatment
• Sun exposure: Strict photoprotection mandatory
• Drug interactions: P-gp inhibitors/inducers require dose adjustment
• Ocular exams: Recommended for persistent eye symptoms
• Diarrhea management: Loperamide protocol essential

What If You Miss a Dose?

If <12 hours late: Take immediately
If >12 hours late: Skip dose, resume next scheduled dose
Never take double dose to compensate

FAQs:

Q1. How will I know if Xovoltib is working?

Response is assessed through CT scans every 8-12 weeks. Symptom improvement (cough, breathlessness) may occur earlier.

Q2. Can I take antacids with Xovoltib?

PPIs should be avoided. H2 blockers may be taken 6 hours before/after Xovoltib. Antacids require 3-hour separation.

Q3. How should I manage skin rash?

Use fragrance-free moisturizers, topical steroids (hydrocortisone 1%), and oral antibiotics (doxycycline) if prescribed.

Q4. Is dose reduction common?

~50% patients require dose reduction (to 30mg then 20mg) for toxicity management without compromising efficacy.

Q5. Can I receive vaccines during treatment?

Live vaccines are contraindicated. Inactivated vaccines may have reduced efficacy – discuss timing with oncologist.

Q6. How should I store Xovoltib?

Store below 25°C in original packaging. The dissolved suspension is stable for 12 hours at room temperature.

Q7. What dietary precautions are needed?

Maintain hydration. Grapefruit should be avoided. Small frequent meals help manage nausea.