Xtane Tablet contains exemestane, a steroidal aromatase inhibitor used for the treatment of estrogen receptor-positive breast cancer in postmenopausal women. This targeted therapy works by permanently binding to and inactivating the aromatase enzyme, thereby dramatically reducing estrogen production in peripheral tissues. Xtane is particularly effective as adjuvant therapy following 2-3 years of tamoxifen treatment, as well as for advanced breast cancer that has progressed on antiestrogen therapy. Clinical studies demonstrate its efficacy in reducing cancer recurrence while maintaining a manageable side effect profile when used as prescribed.

Uses of Xtane Tablet:

• Adjuvant treatment of ER+ early breast cancer in postmenopausal women
• First-line therapy for advanced ER+ breast cancer
• Sequential therapy after 2-3 years of tamoxifen
• Treatment of advanced breast cancer progressing on antiestrogens

Benefits of Xtane Tablet:

• Superior disease-free survival compared to tamoxifen
• Irreversible aromatase inhibition for sustained effect
• Once-daily oral dosing for convenience
• No endometrial stimulation risk
• Proven overall survival benefit in certain subgroups

Side Effects of Xtane Tablet:

Very common (>10%):
• Hot flashes (25-30%)
• Arthralgia (20-25%)
• Fatigue (15-20%)
• Headache (10-15%)

Common (1-10%):
• Osteoporosis/fractures
• Hypercholesterolemia
• Carpal tunnel syndrome
• Depression/insomnia

How to Use Xtane Tablet?

• Standard dose: 25mg once daily after a meal
• Timing: Preferably at the same time each day
• Duration: Typically 2-5 years of adjuvant therapy
• Monitoring: Regular bone density scans and lipid profiles
• Compliance: Critical for optimal outcomes

How Xtane Tablet Works?

Xtane is a Type I aromatase inhibitor that irreversibly binds to the aromatase enzyme’s active site, causing permanent inactivation (suicide inhibition). This blocks the conversion of androgens to estrogens in peripheral tissues (adipose, muscle), reducing circulating estrogen levels by >90%. The dramatic estrogen suppression deprives ER+ breast cancer cells of their primary growth stimulus, leading to tumor regression or growth arrest.

Safety Advice:

• Pregnancy: Absolute contraindication (Category X)
• Bone health: Calcium/vitamin D supplementation recommended
• Lipid monitoring: Regular cholesterol checks advised
• Hepatic impairment: Use with caution in severe liver disease
• Renal impairment: No dose adjustment typically needed
• Drug interactions: Avoid strong CYP3A4 inducers

What If You Miss a Dose?

If <12 hours late: Take immediately
If >12 hours late: Skip dose and resume next scheduled dose
Never take double dose to compensate

FAQs:

Q1. How long until Xtane starts working?

Estrogen suppression begins within days, but clinical response in adjuvant setting takes months. Tumor response in advanced disease may be seen in 4-12 weeks.

Q2. Can premenopausal women take Xtane?

No – ovarian estrogen production overwhelms aromatase inhibition. Requires confirmed postmenopausal status (FSH/estradiol levels if uncertain).

Q3. What’s the best way to manage joint pain?

Regular low-impact exercise, OTC analgesics, and sometimes temporary dose reduction. Symptoms often improve after 6-12 months.

Q4. Should I take calcium supplements?

Yes – 1200mg calcium and 800-1000IU vitamin D daily are recommended to mitigate bone loss, along with baseline DEXA scan.

Q5. Can I take Xtane with food?

Yes – taking with food (especially fatty meals) increases absorption by up to 40%.

Q6. What blood tests are needed?

Baseline and annual lipids, periodic vitamin D, and bone turnover markers if osteoporosis risk is high.

Q7. How does Xtane compare to other AIs?

Similar efficacy to nonsteroidal AIs (anastrozole/letrozole) but with different side effect profile and irreversible mechanism.